{"id":975,"date":"2026-06-11T09:01:08","date_gmt":"2026-06-11T00:01:08","guid":{"rendered":"https:\/\/www.factlog.kr\/?p=975"},"modified":"2026-06-11T09:01:08","modified_gmt":"2026-06-11T00:01:08","slug":"%ec%9a%b0%eb%a6%ac-%eb%aa%b8%ec%9d%98-%ec%9c%a0%ec%a0%84%ec%9e%90-%ec%82%ac%eb%83%a5%ea%be%bc-%ec%95%84%ea%b3%a0%eb%84%9b-%eb%8b%a8%eb%b0%b1%ec%a7%88-%ed%98%95%ec%84%b1-%ea%b3%bc","status":"publish","type":"post","link":"https:\/\/www.factlog.kr\/?p=975","title":{"rendered":"\uc6b0\ub9ac \ubab8\uc758 \uc720\uc804\uc790 \uc0ac\ub0e5\uafbc \u2018\uc544\uace0\ub11b\u2019 \ub2e8\ubc31\uc9c8 \ud615\uc131 \uacfc\uc815 \uaddc\uba85"},"content":{"rendered":"
\n

\"\uc6b0\ub9ac<\/p>\n

\n

– IBS\uff65\uc11c\uc6b8\ub300, \ubca0\uc77c\uc5d0 \uc2f8\uc600\ub358 \uc720\uc804\uc790 \uc870\uc808 \ub2e8\ubc31\uc9c8 \ud65c\uc131\ud654 \uc6d0\ub9ac \uc138\uacc4 \ucd5c\ucd08 \uaddc\uba85<\/p>\n

– RNA \uce58\ub8cc\uc81c \uc124\uacc4\uc758 \uc2dc\ud589\ucc29\uc624\ub97c \uc904\uc77c \uc0c8\ub85c\uc6b4 \ubc29\ud5a5 \uc81c\uc2dc, \uad6d\uc81c\ud559\uc220\uc9c0 Nature\u8a8c \uac8c\uc7ac<\/p>\n

\ub300\uc0ac\uc9c8\ud658, \uc54c\uce20\ud558\uc774\uba38 \ub4f1 \ud2b9\uc815 \uc720\uc804\uc790\uac00 \uacfc\ub3c4\ud558\uac8c \ubc1c\ud604\ub418\uc5b4 \uc0dd\uae30\ub294 \ub09c\uce58\uc131 \uc9c8\ud658\uc758 RNA \uce58\ub8cc\uc81c\ub97c \ubd80\uc791\uc6a9 \uc5c6\uc774 \ubcf4\ub2e4 \uc815\uad50\ud558\uac8c \uc124\uacc4\ud560 \uc218 \uc788\ub294 \uae38\uc774 \uc5f4\ub9b4 \uc804\ub9dd\uc774\ub2e4.<\/p>\n

\uacfc\ud559\uae30\uc220\uc815\ubcf4\ud1b5\uc2e0\ubd80(\ubd80\ucd1d\ub9ac \uacb8 \uacfc\ud559\uae30\uc220\uc815\ubcf4\ud1b5\uc2e0\ubd80 \uc7a5\uad00 \ubc30\uacbd\ud6c8, \uc774\ud558 \u2018\uacfc\uae30\uc815\ud1b5\ubd80\u2019)\ub294 \uae30\ucd08\uacfc\ud559\uc5f0\uad6c\uc6d0(\uc6d0\uc7a5 \uc7a5\uc11d\ubcf5, \uc774\ud558 \u2018IBS\u2019) RNA \uc5f0\uad6c\ub2e8 \uae40\ube5b\ub0b4\ub9ac \ub2e8\uc7a5\uacfc \uc11c\uc6b8\ub300 \uc0dd\uba85\uacfc\ud559\ubd80 \ub178\uc131\ud6c8 \uad50\uc218 \uacf5\ub3d9 \uc5f0\uad6c\ud300\uc774 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \uc870\uc808\ud558\ub294 \ub2e8\ubc31\uc9c8 \u2018\uc544\uace0\ub11b*\u2019\uc758 \ud65c\uc131\ud654 \uacfc\uc815\uc744 \uc138\uacc4 \ucd5c\ucd08\ub85c \uaddc\uba85\ud588\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

* \uc544\uace0\ub11b(Argonaute): \uc6b0\ub9ac \uc138\ud3ec \uc548\uc5d0\uc11c \ud544\uc694 \uc5c6\ub294 \uc720\uc804\uc790 \uc815\ubcf4\ub97c \ucc3e\uc544\ub0b4 \uc81c\uac70\ud558\ub294 \ub2e8\ubc31\uc9c8\ub85c, \uc81c\uac70 \ub300\uc0c1 \uc815\ubcf4\ub97c \ub2f4\uc740 miRNA\uc640 \uacb0\ud569\ud55c \ub4a4, \ud45c\uc801\uc774 \ub418\ub294 \uc804\ub839 RNA(mRNA)\ub97c \ucc3e\uc544\uac00 \ubd84\ud574<\/p>\n

\uacfc\uae30\uc815\ud1b5\ubd80\uc758 IBS \uae30\ucd08\uacfc\ud559\uc5f0\uad6c\ub2e8\uc0ac\uc5c5, \uac1c\uc778\uae30\ucd08\uc5f0\uad6c\uc0ac\uc5c5 \ub4f1\uc758 \uc9c0\uc6d0\uc744 \ud1b5\ud574 \uc774\ub8ec \uc774\ubc88 \uc5f0\uad6c \uc131\uacfc\ub294, \uc544\uace0\ub11b\uc758 \uad6c\uc870 \ud615\uc131\uc744 \ub3d5\ub294 \u2018\uc0e4\ud398\ub860*\u2019 \ub2e8\ubc31\uc9c8\uc758 \uc791\ub3d9 \uc6d0\ub9ac\ub97c \ubc1d\ud788\uace0 \uc544\uace0\ub11b\uc5d0 \uc798 \uacb0\ud569\ud558\ub294 RNA\uc758 \ud2b9\uc131\uc744 \uaddc\uba85\ud568\uc73c\ub85c\uc368 RNA \uce58\ub8cc\uc81c \uc124\uacc4\uc758 \uc0c8\ub85c\uc6b4 \ubc29\ud5a5\uc744 \uc81c\uc2dc\ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \ud070 \uc758\uc758\ub97c \uc9c0\ub2c8\uba70, 6\uc6d4 11\uc77c(\ubaa9) 0\uc2dc(KST) \uad6d\uc81c\ud559\uc220\uc9c0 \u2018\ub124\uc774\ucc98(Nature)\u2019\uc5d0 \uac8c\uc7ac\ub410\ub2e4.<\/p>\n

* \uc0e4\ud398\ub860(Chaperone): \uc138\ud3ec \uc548\uc5d0\uc11c \ub2e4\ub978 \ub2e8\ubc31\uc9c8\uc5d0 \ubd99\uc5b4 \uc815\uc0c1\uc801\uc778 3\ucc28\uc6d0 \uad6c\uc870\ub97c \uac16\ucd94\ub3c4\ub85d \ub3c4\uc640\uc8fc\ub294 \ub2e8\ubc31\uc9c8<\/p>\n

\uc6b0\ub9ac \uc138\ud3ec \uc548\uc5d0\ub294 \uc720\uc804\uc790\uc758 \uacfc\ub3c4\ud55c \ubc1c\ud604\uc744 \uc5b5\uc81c\ud558\uc5ec \uc2e0\uccb4 \uade0\ud615\uc744 \ub9de\ucd94\ub294 \ub9c8\uc774\ud06c\ub85c RNA(miRNA)\uac00 \uc874\uc7ac\ud55c\ub2e4. \uc774 miRNA\uac00 \uc2e4\uc81c\ub85c \uc138\ud3ec \ub0b4\uc5d0\uc11c \uc720\uc804\uc790 \ubc1c\ud604\uc744 \uc5b5\uc81c\ud558\ub824\uba74, \ubc18\ub4dc\uc2dc \uc544\uace0\ub11b \ub2e8\ubc31\uc9c8\uacfc \uacb0\ud569\ud558\uc5ec ‘\ub2e8\ubc31\uc9c8-RNA \ubcf5\ud569\uccb4(RISC*)’\ub97c \ud615\uc131\ud574\uc57c \uac00\ub2a5\ud558\ub2e4.<\/p>\n

* RISC(RNA-Induced Silencing Complex, RNA \uc720\ub3c4 \uce68\ubb35 \ubcf5\ud569\uccb4): \ub9c8\uc774\ud06c\ub85c RNA\uc640 \uc544\uace0\ub11b\uc758 \ubcf5\ud569\uccb4\ub85c\uc11c, \ud45c\uc801 \uc720\uc804\uc790\uc758 \uae30\ub2a5\uc744 \uc5b5\uc81c\ud568.<\/p>\n

\uadf8\ub7ec\ub098 miRNA\uac00 \uc544\uace0\ub11b\uacfc \uacb0\ud569\ud574\uc11c \ud65c\uc131\uc744 \uac00\uc9c0\uac8c \ub418\ub294 \uacfc\uc815\uc740 \uc9c0\uae08\uae4c\uc9c0 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc558\uc73c\uba70, \uc774\ub85c \uc778\ud574 RNA\uce58\ub8cc\uc81c \uac1c\ubc1c\uc5d0\ub3c4 \ud55c\uacc4\uac00 \uc788\uc5c8\ub2e4.<\/p>\n

\uc774\uc5d0 \uc5f0\uad6c\uc9c4\uc740 \uc544\uace0\ub11b\uc774 \uc720\uc804\uc790 \uc870\uc808 \ud65c\uc131\uc744 \uac16\ucd94\ub294 \uacfc\uc815\uc744 \uc9c1\uc811 \uad00\ucc30\ud558\uae30 \uc704\ud574 \uc0e4\ud398\ub860\uc5d0 \uacb0\ud569\ud55c \uc544\uace0\ub11b \ubcf5\ud569\uccb4\ub97c \uc138\uacc4 \ucd5c\ucd08\ub85c \ubd84\ub9ac\u00b7\uc815\uc81c\ud558\uace0 \ucd08\uc800\uc628 \uc804\uc790\ud604\ubbf8\uacbd(Cryo-EM) \uae30\uc220\uc744 \uc774\uc6a9\ud574 \ubcf5\ud569\uccb4\uc758 \uad6c\uc870\ub97c \uc6d0\uc790 \uc218\uc900\uc5d0\uc11c \ubd84\uc11d\ud588\ub2e4.<\/p>\n

\uadf8 \uacb0\uacfc, \uc0e4\ud398\ub860\uc740 \uc544\uace0\ub11b\uc744 \uc644\uc804\ud788 \uc5f4\ub9b0 \ud615\ud0dc\ub85c \ubd99\uc7a1\uc544 miRNA\uac00 \ub4e4\uc5b4\uac08 \uacf5\uac04\uc744 \ub9cc\ub4e4\uc5b4 \uc8fc\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4. \uadf8 \uacf5\uac04\uc5d0 miRNA\uac00 \ub4e4\uc5b4\uac00 \uacb0\ud569\ud558\uba74 \uc784\ubb34\ub97c \ub9c8\uce5c \uc0e4\ud398\ub860\uc740 \ub5a8\uc5b4\uc838 \ub098\uac00\uace0, \uc544\uace0\ub11b\uc740 \uc720\uc804\uc790\ub97c \uc870\uc808\ud560 \uc218 \uc788\ub294 \ub2eb\ud78c \ud615\ud0dc\ub85c \uc644\uc131\ub410\ub2e4.<\/p>\n

\ub610\ud55c, \uc5f0\uad6c\uc9c4\uc740 \uc774 \uc791\ub3d9 \uc6d0\ub9ac\ub97c \uac80\uc99d\ud558\uae30 \uc704\ud574 \uc2dc\ud5d8\uad00 \uc548\uc5d0\uc11c \uacb0\ud569 \uacfc\uc815\uc744 \uadf8\ub300\ub85c \uc7ac\ud604\ud574 \ub0c8\ub2e4. \uadf8 \uacb0\uacfc \uc644\uc131\ub41c \uc544\uace0\ub11b \ubcf5\ud569\uccb4\ub294 \ud45c\uc801 \uc720\uc804\uc790(mRNA)\ub97c \uc815\ud655\ud788 \uc798\ub77c\ub0b4\ub294 \uae30\ub2a5\uae4c\uc9c0 \uc815\uc0c1\uc801\uc73c\ub85c \uc218\ud589\ud588\ub2e4.<\/p>\n

\ud2b9\ud788 \uc138\ud3ec \ub0b4\uc5d0\uc11c \uc874\uc7ac\ud558\ub294 \uc6d0\ub798 \ud615\ud0dc\uc778 \u2018\uc774\uc911\uac00\ub2e5\u2019 miRNA\uac00 \uc788\uc744 \ub54c\ub9cc \uc544\uace0\ub11b\uc774 \uc548\uc815\uc801\uc73c\ub85c \uc791\ub3d9\ud588\uc73c\uba70, miRNA\uac00 \uc5c6\uac70\ub098 \u2018\ub2e8\uc77c\uac00\ub2e5\u2019 \ud615\ud0dc\uc77c \ub54c\ub294 \uc815\uc0c1\uc801\uc778 \uad6c\uc870\uac00 \ub9cc\ub4e4\uc5b4\uc9c0\uc9c0 \uc54a\ub294\ub2e4\ub294 \uc0ac\uc2e4\ub3c4 \ucd94\uac00\ub85c \ud655\uc778\ud588\ub2e4.<\/p>\n

\uc774\ub97c \ud1b5\ud574 \uc5f0\uad6c\uc9c4\uc740 miRNA\uac00 \ub2e8\uc21c\ud788 \uc544\uace0\ub11b\uacfc \uacb0\ud569\ud558\ub294 \ub300\uc0c1\uc774 \uc544\ub2c8\ub77c, \uc544\uace0\ub11b\uc774 \uc62c\ubc14\ub978 \uad6c\uc870\ub97c \uac16\ucd94\ub3c4\ub85d \ub3d5\ub294 \ud575\uc2ec \uc778\uc790\uc784\uc744 \ubc1d\ud614\ub2e4. \uc774\ub294 miRNA\uac00 \uc720\uc804\uc790 \uc870\uc808 \uc815\ubcf4\ub97c \uc804\ub2ec\ud558\ub294 \uc5ed\ud560\uc744 \ub118\uc5b4, \ub2e8\ubc31\uc9c8 \uc870\ub9bd \uacfc\uc815\uc5d0\ub3c4 \ubc00\uc811\ud558\uac8c \uc9c1\uc811 \uad00\uc5ec\ud568\uc744 \ubcf4\uc5ec\uc8fc\ub294 \uc131\uacfc\ub2e4.<\/p>\n

\ub098\uc544\uac00, \uc5f0\uad6c\uc9c4\uc740 \uc5b4\ub5a4 RNA\uac00 \uc544\uace0\ub11b\uc5d0 \ud6a8\uc728\uc801\uc73c\ub85c \ud0d1\uc7ac\ub420 \uc218 \uc788\ub294\uc9c0\ub3c4 \uccb4\uacc4\uc801\uc73c\ub85c \ubd84\uc11d\ud588\ub2e4. \uadf8 \uacb0\uacfc RNA\uc758 \ud654\ud559\uc801 \ud2b9\uc131, \uc774\uc911\ub098\uc120 \uad6c\uc870, 20~24\uac1c \uc5fc\uae30\uc758 \ucd5c\uc801 \uae38\uc774 \ub4f1\uc774 \uc544\uace0\ub11b\uc758 \uc815\uc0c1\uc801\uc778 \uacb0\ud569\uc5d0 \ud544\uc218\uc801\uc784\uc744 \ud655\uc778\ud588\ub2e4.<\/p>\n

\uc544\uc6b8\ub7ec, \ud604\uc7ac \uc784\uc0c1\uc5d0\uc11c \uc0ac\uc6a9 \uc911\uc778 siRNA* \uce58\ub8cc\uc81c\uc758 \ud654\ud559 \uc794\uae30**\uac00 \uc544\uace0\ub11b \uc870\ub9bd\uc5d0 \uc5b4\ub5a4 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294\uc9c0\ub3c4 \ubc1d\ud600\ub0c4\uc73c\ub85c\uc368 \uce58\ub8cc\uc81c \uc124\uacc4\uc758 \ud6a8\uc728\uc131\uacfc \uc751\uc6a9 \uac00\ub2a5\uc131\uc744 \ud06c\uac8c \ub192\uc600\ub2e4.<\/p>\n

* siRNA(Small Interfering RNA, \uc791\uc740 \uac04\uc12d RNA): \ud2b9\uc815 \uc720\uc804\uc790\uc758 \ud65c\ub3d9\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \ucc28\ub2e8\ud558\uc5ec \uc9c8\ubcd1 \uc6d0\uc778 \ub2e8\ubc31\uc9c8\uc774 \ub9cc\ub4e4\uc5b4\uc9c0\uc9c0 \uc54a\ub3c4\ub85d \ud558\ub294 \uc778\uacf5 \ud569\uc131 miRNA (\ucc28\uc138\ub300 \uc2e0\uc57d \ud50c\ub7ab\ud3fc\uc73c\ub85c \uac01\uad11)<\/p>\n

** \ud654\ud559 \uc794\uae30(Chemical Moiety): \uc778\uacf5 RNA \uce58\ub8cc\uc81c\uac00 \uc6b0\ub9ac \ubab8\uc18d\uc5d0\uc11c \uc27d\uac8c \ubd84\ud574\ub418\uc9c0 \uc54a\uace0 \uc624\ub7ab\ub3d9\uc548 \uc0b4\uc544\ub0a8\uc544 \ud6a8\uacfc\ub97c \ub0bc \uc218 \uc788\ub3c4\ub85d \ubf08\ub300\uc5d0 \uc778\uc704\uc801\uc73c\ub85c \ub367\ubd99\uc778 \ud2b9\uc218 \ud654\ud559 \ubd84\uc790 \uc870\uac01.<\/p>\n

\uae40\ube5b\ub0b4\ub9ac \uc5f0\uad6c\ub2e8\uc7a5\uc740 \u201c\uadf8\ub3d9\uc548 \uc2dc\ud589\ucc29\uc624\uc5d0 \uc758\uc874\ud558\ub358 RNA \uce58\ub8cc\uc81c \uc124\uacc4\uc5d0 \ubd84\uc790\uc801\uff65\uc774\ub860\uc801 \uadfc\uac70\ub97c \uc81c\uc2dc\ud55c \uac83\u201d\uc774\ub77c\uba70, \u201c\uc774\ub97c \uc774\uc6a9\ud574 \ud5a5\ud6c4 \ubcf4\ub2e4 \ud6a8\uc728\uc801\uc774\uace0 \uc548\uc804\ud55c siRNA \uce58\ub8cc\uc81c\ub97c \uac1c\ubc1c\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4\u201d\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\ub178\uc131\ud6c8 \uad50\uc218\ub294 \u201c\uc774\ubbf8 \uc644\uc131\ub41c \uad6c\uc870\uac00 \uc544\ub2c8\ub77c \ub2e8\ubc31\uc9c8\uc774 \uae30\ub2a5\uc744 \uac16\ucd94\uc5b4 \uac00\ub294 \uacfc\uc815\uc744 \uc9c1\uc811 \uad00\ucc30\ud55c \ub370 \uc758\ubbf8\uac00 \ud06c\ub2e4\u201d\ub77c\uba70, \u201c\ub2e8\ubc31\uc9c8 \uc870\ub9bd \uc6d0\ub9ac\ub97c \uaddc\uba85\ud568\uc73c\ub85c\uc368 \uc0dd\ubb3c \ud604\uc0c1 \uc774\ud574\ud558\ub294 \uc0c8\ub85c\uc6b4 \uad00\uc810\uc744 \uc81c\uc2dc\ud560 \uac83\u201d\uc774\ub77c\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n

\uacfc\uae30\uc815\ud1b5\ubd80 \uae40\uc131\uc218 \uc5f0\uad6c\uac1c\ubc1c\uc2e4\uc7a5\uc740 \u201c\uc774\ubc88 \uc5f0\uad6c \uc131\uacfc\ub294 \uc6b0\ub9ac \uc0dd\uba85\uc5d0 \ub300\ud55c \uc774\ud574\uc640 \uce58\ub8cc\uc758 \ud3ed\uc744 \ub113\ud600\uac08 \uae30\ucd08\uacfc\ud559 \uc5f0\uad6c\uc758 \uc18c\uc911\ud55c \uacb0\uc2e4\u201d\uc774\ub77c\uba70, \u201c\uc774\ub7ec\ud55c \uc6d0\ucc9c\uc9c0\uc2dd\uc774 \uad6d\uac00 \uacbd\uc7c1\ub825\uc758 \uac00\uc7a5 \ub2e8\ub2e8\ud55c \ud1a0\ub300\uac00 \ub418\ub294 \ub9cc\ud07c, \uc5f0\uad6c\uc790\ub4e4\uc774 \uc624\ub86f\uc774 \uc5f0\uad6c\uc5d0\ub9cc \uc804\ub150\ud560 \uc218 \uc788\ub3c4\ub85d \uafb8\uc900\ud788 \uc9c0\uc6d0\ud574 \ub098\uac00\uaca0\ub2e4\u201d\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

.*<\/p>\n\n\n
\uc5f0 \uad6c \ucd94 \uac00 \uc124 \uba85<\/td>\n<\/tr>\n<\/table>\n\n\n\n\n
\ub17c\ubb38\/\uc800\ub110\/\uc800\uc790<\/td>\nStructural basis for chaperone-guided assembly of RNA-induced silencing complex \/ Nature (2026)
\uc774\uc601\uc724(\uacf5\ub3d9 \uc81c1\uc800\uc790, IBS\/\uc11c\uc6b8\ub300), \uc815\ubbfc\uc11d(\uacf5\ub3d9 \uc81c1\uc800\uc790, IBS\/\uc11c\uc6b8\ub300), \uc774\ud55c\uc194(\uacf5\ub3d9 \uc81c1\uc800\uc790, \uc11c\uc6b8\ub300), \uc774\ub2e4\ub2c8\uc5d8(IBS\/\uc11c\uc6b8\ub300), \uc774\uc7ac\ud604(\uc11c\uc6b8\ub300), \ubc15\uc900\uc120(\uc11c\uc6b8\ub300), \uae40\ube5b\ub0b4\ub9ac(\uacf5\ub3d9 \uad50\uc2e0\uc800\uc790, IBS\/\uc11c\uc6b8\ub300), \ub178\uc131\ud6c8(\uacf5\ub3d9 \uad50\uc2e0\uc800\uc790, \uc11c\uc6b8\ub300)<\/td>\n<\/tr>\n
\uc5f0\uad6c\ub0b4\uc6a9
\ubcf4\ucda9\uc124\uba85<\/td>\n		\uc544\uace0\ub11b\uc740 miRNA\uc640 \uacb0\ud569\ud574\uc57c\ub9cc \ube44\ub85c\uc18c \uc720\uc804\uc790 \uc870\uc808 \uae30\ub2a5\uc744 \uc218\ud589\ud560 \uc218 \uc788\ub2e4. \uadf8\ub7ec\ub098 \uc544\uace0\ub11b\uc774 \uc5b4\ub5bb\uac8c miRNA\ub97c \ubc1b\uc544\ub4e4\uc5ec \uae30\ub2a5\uc801\uc73c\ub85c \uc644\uc131\ub418\ub294\uc9c0, \uadf8 \uacfc\uc815\uc740 \uc624\ub7ab\ub3d9\uc548 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc558\ub2e4. \uc138\ud3ec \uc548\uc758 \uc544\uace0\ub11b\uc740 \ub300\ubd80\ubd84 miRNA\uc640 \uc774\ubbf8 \uacb0\ud569\ud55c \uc0c1\ud0dc\ub85c \uc874\uc7ac\ud558\uae30 \ub54c\ubb38\uc5d0, \uadf8 \uc9c1\uc804 \ub2e8\uacc4\ub97c \ud3ec\ucc29\ud558\ub294 \uac83 \uc790\uccb4\uac00 \uadfc\ubcf8\uc801\uc778 \uc5b4\ub824\uc6c0\uc774\uc5c8\ub2e4.
\uc774\ubc88 \uc5f0\uad6c\ub294 \uc0e4\ud398\ub860\uc774 \ubc14\ub85c \uadf8 \uc9c1\uc804 \ub2e8\uacc4\uc758 \uc544\uace0\ub11b\uc744 \ubd99\uc7a1\uc544 \ub300\uae30\uc2dc\ud0a8\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1d\ud788\uace0, \uc774 \u2018\uc544\uace0\ub11b \uc131\uc219 \ubcf5\ud569\uccb4(AGO maturation complex, AMC)\u2019\ub97c \uc138\uacc4 \ucd5c\ucd08\ub85c \ubd84\ub9ac\u00b7\uc815\uc81c\ud574 \uad6c\uc870\uc640 \uae30\ub2a5\uc744 \uaddc\uba85\ud588\ub2e4. \ucd08\uc800\uc628\uc804\uc790\ud604\ubbf8\uacbd(Cryo-EM)\uc73c\ub85c \ud3ec\ucc29\ud55c AMC\uc758 \uad6c\uc870\ub294 \uc0e4\ud398\ub860\uc774 \uc544\uace0\ub11b\uc744 \uc644\uc804\ud788 \uc5f4\ub9b0 \ud615\ud0dc\ub85c \ubd99\uc7a1\uace0 \uc788\ub294 \ubaa8\uc2b5\uc744 \ubcf4\uc5ec\uc900\ub2e4. \uc5ec\ub7ec \ub3c4\uba54\uc778\uc744 \uac00\uc9c4 \ub2e8\ubc31\uc9c8\uc774 \uc774\ucc98\ub7fc \uc644\uc804\ud788 \uc5f4\ub9b0 \ucc44 \ud3ec\ucc29\ub41c \uc911\uac04\uccb4\uc758 \uad6c\uc870\ub294 \uadf8\ub3d9\uc548 \uc5b4\ub5a4 \ub2e8\ubc31\uc9c8\uc5d0\uc11c\ub3c4 \uc81c\ub300\ub85c \uad00\ucc30\ub41c \uc801\uc774 \uc5c6\ub2e4.
\ub610\ud55c \uc774\ubc88 \uc5f0\uad6c\ub294 miRNA\uc758 \uc5ed\ud560\uc5d0 \ub300\ud55c \uae30\uc874 \ud1b5\ub150\uc744 \ub4a4\uc9d1\uc5c8\ub2e4. \uc9c0\uae08\uae4c\uc9c0 miRNA\ub294 \uc544\uace0\ub11b\uc5d0 \ud0d1\uc7ac\ub418\uc5b4\uc57c \ud560 ‘\ubb3c\uac74’\ucc98\ub7fc \uc5ec\uaca8\uc84c\ub2e4. \uc774\ubbf8 \uc811\ud600\uc788\ub294 \ube48 \uc0c1\uc790(\uc544\uace0\ub11b)\uc5d0 \ubb3c\uac74(miRNA)\uc744 \ub2f4\uc544 \ud3ec\uc7a5\ud558\ub294 \uac83\uacfc \uac19\ub2e4\uace0 \ubcf8 \uac83\uc774\ub2e4. \uadf8\ub7ec\ub098 \uc774\ubc88 \uc5f0\uad6c\ub294 miRNA\uac00 \ub2e8\uc21c\ud788 \uc2e4\ub9ac\ub294 \ub300\uc0c1\uc774 \uc544\ub2c8\ub77c, \uc544\uace0\ub11b\uc758 \uc644\uc131\uc744 \uacb0\uc815\ud558\ub294 \ub2a5\ub3d9\uc801 \uc694\uc18c\uc784\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\ub2e4. \ubb3c\uac74\uc774 \uc5c6\uc73c\uba74 \ube48 \uc0c1\uc790\ub77c\ub3c4 \ubbf8\ub9ac \uc811\uc5b4\ub193\uc744 \uc218 \uc788\ub2e4\uace0 \uc0dd\uac01\ud588\ub358 \uac83\uacfc \ub2ec\ub9ac, \uc2e4\uc81c\ub85c\ub294 \ubb3c\uac74\uc744 \uace8\uaca9\uc73c\ub85c \uc0bc\uc544\uc57c \ube44\ub85c\uc18c \uc0c1\uc790\ub97c \uc811\uc744 \uc218 \uc788\uc5c8\ub358 \uc148\uc774\ub2e4. \uc774\ub294 \ub2e8\ubc31\uc9c8\uc758 \uc644\uc131\uc774 RNA\uc758 \ud0d1\uc7ac\uc640 \ub9de\ubb3c\ub824 \uc77c\uc5b4\ub098\ub294 \uac83\uc73c\ub85c, \ub2e8\ubc31\uc9c8 \uc811\ud798\uc758 \uc6d0\ub9ac\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \ud1b5\ucc30\uc744 \uc81c\uc2dc\ud55c\ub2e4.
\uc774\ubc88 \uc5f0\uad6c\uc758 \uc131\uacfc\ub294 siRNA \uce58\ub8cc\uc81c \uc124\uacc4\uc5d0\ub3c4 \uc9c1\uacb0\ub41c\ub2e4. \ud604\uc7ac \uc784\uc0c1\uc5d0\uc11c \uc0ac\uc6a9\ub418\ub294 siRNA \uce58\ub8cc\uc81c\ub294 \uccb4\ub0b4 \uc548\uc815\uc131\uc744 \ub192\uc774\uae30 \uc704\ud574 \ud654\ud559\uc801 \ubcc0\ud615\uc744 \uc801\uc6a9\ud558\uc9c0\ub9cc, \ubcc0\ud615\uc758 \uc885\ub958\uc640 \uc704\uce58 \uc870\ud569\uc774 \ucc9c\ubb38\ud559\uc801\uc73c\ub85c \ub9ce\uc544 \uadf8\ub3d9\uc548 \uc218\ucc9c \uac00\uc9c0 \uc870\ud569\uc744 \uc77c\uc77c\uc774 \ud569\uc131\u00b7\uac80\uc99d\ud558\ub294 \ubc29\ub300\ud55c \uc2a4\ud06c\ub9ac\ub2dd\uc5d0 \uc758\uc874\ud574 \uc654\ub2e4. \uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc544\uace0\ub11b\uc5d0 \ud6a8\uc728\uc801\uc73c\ub85c \ud0d1\uc7ac\ub418\uae30 \uc704\ud55c RNA\uc758 \uc870\uac74\uc744 \uc9c1\uc811 \uaddc\uba85\ud588\uc73c\uba70, \ud655\ub9bd\ud55c \uc2dc\ud5d8\uad00 \ub0b4 \uc7ac\uad6c\uc131 \uc2dc\uc2a4\ud15c\uc740 \uc0c8\ub85c\uc6b4 RNA \uc124\uacc4\uc758 \uc544\uace0\ub11b \ud638\ud658\uc131\uc744 \uac80\uc99d\ud558\ub294 \ud50c\ub7ab\ud3fc\uc73c\ub85c\ub3c4 \ud65c\uc6a9\ub420 \uc218 \uc788\ub2e4. \uc774\ub294 \uc2dc\ud589\ucc29\uc624\uc5d0 \uc758\uc874\ud574 \uc628 siRNA \uce58\ub8cc\uc81c \uc124\uacc4\uc5d0 \ucc98\uc74c\uc73c\ub85c \ubd84\uc790 \uc218\uc900\uc758 \uadfc\uac70\ub97c \uc81c\uacf5\ud55c \uac83\uc73c\ub85c, \ucc28\uc138\ub300 RNA \uce58\ub8cc\uc81c\ub97c \ubcf4\ub2e4 \uc815\ubc00\ud558\uac8c \uc124\uacc4\ud558\ub294 \ub370 \ud65c\uc6a9\ub420 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4.<\/td>\n<\/tr>\n
\uc5f0\uad6c \uc774\uc57c\uae30<\/td>\n[\uc5f0\uad6c \uacfc\uc815]
IBS RNA \uc5f0\uad6c\ub2e8\uc740 \uc9c0\ub09c 25\ub144\uac04 miRNA\uac00 \ub9cc\ub4e4\uc5b4\uc9c0\ub294 \uacfc\uc815\uc5d0 \ub300\ud55c \ucd5c\ucd08\uc758 \uac00\uc124\uc744 \uc81c\uc2dc\ud588\uc744 \ubfd0 \uc544\ub2c8\ub77c, \uadf8 \uc0dd\ud569\uc131\uc744 \ub2f4\ub2f9\ud558\ub294 \uc778\uc790\ub4e4\uc744 \ubc1c\uacac\ud588\ub2e4. \ub610\ud55c \uc0dd\ud569\uc131 \uacbd\ub85c\uc758 \ud575\uc2ec \ud6a8\uc18c\uc778 \ub4dc\ub85c\uc154, \ub2e4\uc774\uc11c, \uc544\uace0\ub11b\uc774 \ubd84\uc790 \uc218\uc900\uc5d0\uc11c \uc5b4\ub5bb\uac8c \uc791\ub3d9\ud558\ub294\uc9c0\ub97c \ubc1d\ud788\ub294 \uc5f0\uad6c\ub97c \uc774\uc5b4\uc654\ub2e4. \ud2b9\ud788 2016\ub144\uc5d0\ub294 \uc778\uac04 \ub4dc\ub85c\uc154\uc758 \uad6c\uc870\ub97c \ucd5c\ucd08\ub85c \uaddc\uba85\ud558\uace0, 2023\ub144\uc5d0\ub294 \uc778\uac04 \ub2e4\uc774\uc11c\uc758 \uad6c\uc870\ub97c \ud480\uc5b4, miRNA \uc0dd\ud569\uc131 \uacbd\ub85c \uc804\ubc18\uc5d0 \ub300\ud55c \uae4a\uc774 \uc788\ub294 \uc774\ud574\uac00 \uac00\ub2a5\ud558\uac8c \ud588\ub2e4.
\uadf8\ub7ec\ub098 \uc774 \ud6a8\uc18c\ub4e4\uc774 \ub9cc\ub4e4\uc5b4\ub0b8 miRNA\uac00 \ucd5c\uc885\uc801\uc73c\ub85c \uc544\uace0\ub11b\uc5d0 \ud0d1\uc7ac\ub418\uace0 \ud65c\uc131\uc744 \ud68d\ub4dd\ud558\ub294 \ub9c8\uc9c0\ub9c9 \ub2e8\uacc4\ub294, \uc624\ub7ab\ub3d9\uc548 \ud480\ub9ac\uc9c0 \uc54a\uc740 \uc219\uc81c\ub85c \ub0a8\uc544\uc788\uc5c8\ub2e4. \uae30\uc874\uc5d0\ub294 \ub2e4\uc774\uc11c\uac00 \uc774 \uacfc\uc815\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud560 \uac83\uc774\ub77c\ub294 \uacac\ud574\uac00 \uc9c0\ubc30\uc801\uc774\uc5c8\uace0, \uc5f0\uad6c\ud300 \uc5ed\uc2dc \uc774\ub97c \ucd9c\ubc1c\uc810\uc73c\ub85c \uc0bc\uc558\ub2e4. \uadf8\ub7ec\ub098 \ub2e4\uc774\uc11c\uc640 \uc544\uace0\ub11b\uc744 \uc774\uc6a9\ud55c \uad6c\uc870 \ubd84\uc11d\uacfc \uae30\ub2a5 \uc7ac\ud604\uc740 \uacc4\uc18d\ud574\uc11c \ubcbd\uc5d0 \ubd80\ub52a\ud614\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc2dc\uc57c\ub97c \ub113\ud600 \uc0e4\ud398\ub860 \ub2e8\ubc31\uc9c8\uc758 \uc5ed\ud560\uc5d0 \uc8fc\ubaa9\ud558\uae30 \uc2dc\uc791\ud588\uace0, \ub73b\ubc16\uc5d0\ub3c4 \uc138\ud3ec \uc548\uc5d0 \uc544\uace0\ub11b-\uc0e4\ud398\ub860 \ubcf5\ud569\uccb4\uac00 \uc774\ubbf8 \uc0c1\ub2f9\ub7c9 \uc874\uc7ac\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\ub2e4.
\uc5f0\uad6c\ud300\uc740 \uc804\ub7b5\uc744 \ubc14\uafd4 \uc774 \ubcf5\ud569\uccb4\ub97c \uc138\ud3ec\ub85c\ubd80\ud130 \uc9c1\uc811 \ubd84\ub9ac\u00b7\uc815\uc81c\ud558\ub294 \ub370 \uc131\uacf5\ud588\uace0, \uc774\ub97c ‘\uc544\uace0\ub11b \uc131\uc219 \ubcf5\ud569\uccb4(AGO maturation complex, AMC)’\ub77c \uba85\uba85\ud588\ub2e4. 25\ub144\uc5d0 \uac78\uce5c \uc5f0\uad6c\uc758 \ud750\ub984 \uc704\uc5d0\uc11c, \uc774\ubc88 \uc131\uacfc\ub294 \ubc1c\uc0c1\uc758 \uc804\ud658\uacfc \ub048\uc9c8\uae34 \uc2dc\ub3c4 \ub05d\uc5d0 \uc5bb\uc5b4\uc9c4 \uac83\uc774\ub2e4.
[\uc5b4\ub824\uc6e0\ub358 \uc810]
\uc138\ud3ec \uc548\uc758 \uc544\uace0\ub11b\uc740 \ub300\ubd80\ubd84 miRNA\uc640 \ub2e8\ub2e8\ud788 \uacb0\ud569\ud55c \uc0c1\ud0dc\ub85c \uc874\uc7ac\ud558\uae30 \ub54c\ubb38\uc5d0, \uc77c\ubc18\uc801\uc73c\ub85c miRNA\uac00 \uacb0\ud569\ud558\uc9c0 \uc54a\uc740 \ube44\uc5b4 \uc788\ub294 \uc544\uace0\ub11b\uc744 \uac00\uc9c0\uace0 \uc5f0\uad6c\ud558\uae30\ub294 \ub9e4\uc6b0 \uc5b4\ub835\ub2e4. \uadf8\ub7ec\ub098 \uc5f0\uad6c\ud300\uc774 \uc815\uc81c\ud55c AMC\ub294 \ub2e4\uc591\ud55c \uc2e4\ud5d8\uc744 \ud558\uae30\uc5d0 \ucda9\ubd84\ud55c \uc591\uc73c\ub85c \ud655\ubcf4\ub418\uc5c8\uc744 \ubfd0 \uc544\ub2c8\ub77c, miRNA\uac00 \uc804\ud600 \uacb0\ud569\ub418\uc9c0 \uc54a\uc740 \uc644\uc804\ud788 \ube44\uc5b4\uc788\ub294 \uc0c1\ud0dc\uc600\ub2e4. \uc544\uace0\ub11b\uc774 \uc544\uc9c1 miRNA\uc640 \uacb0\ud569\ud558\uc9c0 \uc54a\uc740 \uc0c1\ud0dc\uc5d0\uc11c, \uc0e4\ud398\ub860\uc774 \uc774\ub97c \ubd99\uc7a1\uc544 \ub300\uae30\uc2dc\ud0a4\ub294 \uc911\uac04 \ub2e8\uacc4\ub97c \ucc98\uc74c\uc73c\ub85c \ud3ec\ucc29\ud55c \uac83\uc774\ub2e4.
\uc774\ub807\uac8c \uc815\uc81c\ud55c AMC\ub97c \ub2e4\ub8e8\ub294 \uc77c\uc740 \ub610 \ub2e4\ub978 \uc5b4\ub824\uc6c0\uc774\uc5c8\ub2e4. \uadf8\uc804\uae4c\uc9c0 \uc21c\uc218 \uc815\uc81c\ub41c \uc0e4\ud398\ub860 \ubcf5\ud569\uccb4\ub97c \uc0dd\ud654\ud559 \uc2e4\ud5d8\uc5d0 \uc9c1\uc811 \ud65c\uc6a9\ud55c \uc0ac\ub840\uac00 \uc5c6\uc5c8\ub2e4. \uc774 \ub54c\ubb38\uc5d0 \ubcf5\ud569\uccb4\uc758 \ubb3c\uc131\uacfc, \ub2e4\ub8e8\uae30\uc5d0 \uae4c\ub2e4\ub85c\uc6b4 \ud2b9\uc131\ub4e4\uc744 \ud558\ub098\ud558\ub098 \uc9c1\uc811 \ud655\uc778\ud574\uc57c \ud588\ub2e4. \ud2b9\ud788 \ubcf5\ud569\uccb4\ub97c \uc548\uc815\ub418\uac8c \uc720\uc9c0\ud558\uace0 \uc6d0\ud558\ub294 \ubc29\ud5a5\uc73c\ub85c \uc870\uc791\ud558\uae30 \uc704\ud55c \uc870\uac74\ub4e4\uc744 \ucc3e\uc544\ub098\uac00\ub294 \uacfc\uc815\uc5d0 \ub9ce\uc740 \uc2dc\uac04\uc774 \uc18c\uc694\ub418\uc5c8\ub2e4.
[\uc131\uacfc \ucc28\ubcc4\uc810]
\uccab\uc9f8, \ub2e8\ubc31\uc9c8\uc774 \uc644\uc131\ub418\uae30 \uc9c1\uc804\uc758 \u2018\ubbf8\uc644\uc131 \uc21c\uac04’\uc744 \ud3ec\ucc29\ud588\ub2e4. \uc5f0\uad6c\uc790\ub4e4\uc740 \uadf8\ub3d9\uc548 \uc644\uc131\ub41c \ub2e8\ubc31\uc9c8\uc758 \uad6c\uc870\ub97c \uc8fc\ub85c \uaddc\uba85\ud574\uc654\uc73c\ub098, \uc774\ubc88\uc5d0 \uaddc\uba85\ud55c AMC \uad6c\uc870\ub294 \uc544\uace0\ub11b\uc774 \ub450 \ubd80\ubd84\uc73c\ub85c \uc644\uc804\ud788 \ubc8c\uc5b4\uc9c4 \ucc44 \uc0e4\ud398\ub860\uc5d0 \ubd99\uc7a1\ud600 \uc788\ub294 \uc811\ud798 \uc911\uac04\uccb4(folding intermediate)\ub85c, \uc544\uc9c1 \uc644\uc131\ub418\uc9c0 \uc54a\uc740 \uc0c1\ud0dc\uc774\ub2e4.
\ub458\uc9f8, RNA\uac00 \ub2e8\ubc31\uc9c8\uc758 \uc644\uc131\uc744 \uc774\ub048\ub2e4\ub294 \uc0c8\ub85c\uc6b4 \uad00\uc810\uc744 \uc81c\uc2dc\ud588\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 miRNA\uac00 \ub2e8\uc21c\ud788 \uc544\uace0\ub11b\uc5d0 \ud0d1\uc7ac\ub418\ub294 \ub300\uc0c1\uc774 \uc544\ub2c8\ub77c, \uc544\uace0\ub11b\uc758 \uae30\ub2a5\uc801 \uc644\uc131\uc744 \uacb0\uc815\ud558\ub294 \ub2a5\ub3d9\uc801 \uc694\uc18c\uc784\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\ub2e4.
\uc14b\uc9f8, \uc784\uc758\uc758 RNA\uc5d0 \ub300\ud574 \uc544\uace0\ub11b \ud638\ud658\uc131\uc744 \uc2dc\ud5d8\ud560 \uc218 \uc788\ub294 \ub3c4\uad6c\ub97c \ud655\ubcf4\ud588\ub2e4. \ube44\uc5b4\uc788\ub294 AMC\ub97c \uc774\uc6a9\ud574 \uc6d0\ud558\ub294 RNA\ub97c \ub123\uc740 \uc544\uace0\ub11b\uc744 \ub9cc\ub4e4 \uc218 \uc788\ub2e4\ub294 \uc810\uc5d0\uc11c, \ud504\ub85c\uadf8\ub798\ubc0d \uac00\ub2a5\ud55c \uc544\uace0\ub11b \uc870\ub9bd \uc2dc\uc2a4\ud15c\uc744 \uad6c\ucd95\ud55c \uac83\uc774\ub77c\uace0 \ud560 \uc218 \uc788\ub2e4.
\ub137\uc9f8, \uc774 \uc2dc\uc2a4\ud15c\uc744 \ud65c\uc6a9\ud574 \ud604\uc7ac \uc784\uc0c1\uc5d0\uc11c \uc2e4\uc81c\ub85c \uc0ac\uc6a9 \uc911\uc778 siRNA \uce58\ub8cc\uc81c\ub4e4\uc758 \ud654\ud559\uc801 \ubcc0\ud615\uc774 \uc544\uace0\ub11b \uae30\ub2a5 \ud68d\ub4dd\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc9c1\uc811 \ud655\uc778\ud568\uc73c\ub85c\uc368, \uc2dc\ud589\ucc29\uc624\uc5d0 \uc758\uc874\ud574 \uc628 siRNA \uce58\ub8cc\uc81c \uc124\uacc4\uc5d0 \ucc98\uc74c\uc73c\ub85c \ubd84\uc790 \uc218\uc900\uc758 \uadfc\uac70\ub97c \uc81c\uacf5\ud588\ub2e4.
\uc5f0\uad6c\ud300\uc774 \ubc1c\uacac\ud55c \ubcf5\ud569\uccb4\uc5d0 \u2018\uc544\uace0\ub11b \uc131\uc219 \ubcf5\ud569\uccb4(AGO maturation complex, AMC)’\ub77c\ub294 \uc774\ub984\uc744 \ubd99\uc778 \ub370\uc5d0\ub294 \ub450 \ubd84\uc57c\uc758 \uc5b8\uc5b4\ub97c \ub3d9\uc2dc\uc5d0 \ub2f4\uc73c\ub824\ub294 \uc758\ub3c4\uac00 \uc788\ub2e4. RNA \uc0dd\ubb3c\ud559\uc5d0\uc11c\ub294 \uc544\uace0\ub11b\uacfc miRNA\uac00 \uacb0\ud569\ud574 \uc644\uc131\ub418\ub294 \uae30\ub2a5\uc131 \ubcf5\ud569\uccb4\ub97c ‘mature RISC’\ub77c \ubd80\ub974\uace0, \uc0e4\ud398\ub860 \uc0dd\ubb3c\ud559\uc5d0\uc11c\ub294 \ub2e8\ubc31\uc9c8\uc774 \uc62c\ubc14\ub974\uac8c \uc811\ud600 \uae30\ub2a5\uc744 \uac16\ucd94\ub294 \uacfc\uc815\uc744 ‘maturation(\uc131\uc219)’\uc774\ub77c \ubd80\ub978\ub2e4. AMC\ub77c\ub294 \uc774\ub984\uc740 RNA \uc0dd\ubb3c\ud559\uc758 \uad00\uc810\uc5d0\uc11c\ub294 \ud65c\uc131\ud654\ub41c \uc544\uace0\ub11b\uc758 \uc644\uc131\uc744, \uc0e4\ud398\ub860 \uc0dd\ubb3c\ud559\uc758 \uad00\uc810\uc5d0\uc11c\ub294 \ub2e8\ubc31\uc9c8\uc774 \uc62c\ubc14\ub978 \uad6c\uc870\ub85c \uc131\uc219\ud574 \uac00\ub294 \uacfc\uc815\uc744 \ub3d9\uc2dc\uc5d0 \ub098\ud0c0\ub0b8\ub2e4. \uc774\ucc98\ub7fc \uc774\ubc88 \uc5f0\uad6c\ub294 RNA \uc0dd\ubb3c\ud559, \uc0e4\ud398\ub860 \uc0dd\ubb3c\ud559, RNA \uce58\ub8cc\uc81c \uac1c\ubc1c\uc774 \uad50\ucc28\ud558\ub294 \ub2e4\ud559\uc81c\uc801 \uc131\uacfc\ub85c, \uac01 \ubd84\uc57c\uc5d0 \uc0c8\ub85c\uc6b4 \uc9c8\ubb38\uacfc \uad00\uc810\uc744 \ub3d9\uc2dc\uc5d0 \ub358\uc9c0\uace0 \uc788\ub2e4.
[\ud5a5\ud6c4 \uc5f0\uad6c\uacc4\ud68d]
\uc5f0\uad6c\ud300\uc740 \uc774\ubc88\uc5d0 \ud655\ubcf4\ud55c AMC \uae30\ubc18 \uc2dc\uc2a4\ud15c\uc744 \ud65c\uc6a9\ud574, \ub2e4\uc591\ud55c RNA\uac00 \uc544\uace0\ub11b\uc5d0 \ud0d1\uc7ac\ub418\ub294 \uc6d0\ub9ac\ub97c \ubcf4\ub2e4 \uc815\ubc00\ud558\uac8c \uaddc\uba85\ud574 \ub098\uac08 \uacc4\ud68d\uc774\ub2e4. \uc774\ub97c \ud1b5\ud574 \ucc28\uc138\ub300 siRNA \uce58\ub8cc\uc81c\uc758 \uc124\uacc4 \ud6a8\uc728\uc744 \ub192\uc774\uace0, \uc720\uc804\u00b7\ub300\uc0ac\uc9c8\ud658\uc744 \ube44\ub86f\ud55c \ub2e4\uc591\ud55c \uc9c8\ubcd1\uc758 \uce58\ub8cc\uc5d0 \uc801\uc6a9\ud560 \uc218 \uc788\ub294 \uae30\ubc18\uc744 \ub113\ud600\ub098\uac08 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4.<\/td>\n<\/tr>\n<\/table>\n\n\n
\uadf8 \ub9bc \uc124 \uba85<\/td>\n<\/tr>\n<\/table>\n

[\uadf8\ub9bc] \uc544\uace0\ub11b\uc774 \ud45c\uc801 \uc720\uc804\uc790 \uc5b5\uc81c \uae30\ub2a5\uc744 \ud68d\ub4dd\ud558\ub294 \uacfc\uc815<\/p>\n

a. \uc544\uace0\ub11b(AGO)\uc740 miRNA\ub97c \uc774\uc6a9\ud574 \ud2b9\uc815 \ud45c\uc801 \uc720\uc804\uc790(mRNA)\ub97c \ucc3e\uc544\ub0b4\ub294 \ub2e8\ubc31\uc9c8\uc774\ub2e4. \ube44\uc5b4 \uc788\ub294 \uc544\uace0\ub11b\uc740 \uc774\uc911\uac00\ub2e5 miRNA\ub97c \ubc1b\uc544\ub4e4\uc778 \ub4a4 \uadf8\uc911 \ud55c \uac00\ub2e5\uc744 \uc120\ud0dd\ud558\uace0, \uadf8 RNA\uc640 \uc11c\uc5f4\uc774 \ub9de\ub294 \ud45c\uc801 \uc720\uc804\uc790\ub97c \ucc3e\uc544 \uc120\ud0dd\uc801\uc73c\ub85c \ubc1c\ud604\uc744 \uc5b5\uc81c\ud55c\ub2e4.<\/p>\n

b. \ucd5c\uc885\uc801\uc73c\ub85c \ub9cc\ub4e4\uc5b4\uc9c0\ub294 \ud65c\uc131 \uc544\uace0\ub11b\u2013miRNA \ubcf5\ud569\uccb4\ub294 \ub2e8\ub2e8\ud558\uac8c \ub2eb\ud78c \uad6c\uc870\uc784\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0, \ud06c\uae30\uac00 \ud070 \uc774\uc911\uac00\ub2e5 miRNA\uac00 \uc5b4\ub5bb\uac8c \ub4e4\uc5b4\uac08 \uc218 \uc788\ub294\uc9c0\ub294 \uc624\ub7ab\ub3d9\uc548 \ud480\ub9ac\uc9c0 \uc54a\uc740 \uc9c8\ubb38\uc774\uc5c8\ub2e4. \ud2b9\ud788 \uc774 \uacfc\uc815\uc5d0\uc11c \uc0e4\ud398\ub860\uc774 \uc5b4\ub5a4 \uc5ed\ud560\uc744 \ud558\ub294\uc9c0\ub294 \uc54c\ub824\uc9c0\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n

c. \uc0e4\ud398\ub860 \ub2e8\ubc31\uc9c8\ub4e4\uc740 \uc544\uace0\ub11b\uc744 \uc644\uc804\ud788 \uc5f4\ub9b0 \ud615\ud0dc\ub85c \ubd99\uc7a1\uc544 \uc774\uc911\uac00\ub2e5 miRNA\uac00 \ub4e4\uc5b4\uac08 \uc218 \uc788\ub294 \ucda9\ubd84\ud55c \uacf5\uac04\uc744 \ub9cc\ub4e4\uc5b4 \uc774 \ubb38\uc81c\ub97c \ud574\uacb0\ud55c\ub2e4. miRNA\uac00 \uacb0\ud569\ub41c \ud6c4\uc5d0\ub294 \uc0e4\ud398\ub860\uc774 \ub5a8\uc5b4\uc838 \ub098\uac00\uace0, \ub450 \uac00\ub2e5 \uc911 \ubd88\ud544\uc694\ud55c \ud55c \uac00\ub2e5\uc774 \uc81c\uac70\ub418\uace0 \uc120\ud0dd\ub41c \ud55c \uac00\ub2e5\ub9cc\uc744 \uc720\uc9c0\ud55c \ucc44 \uc544\uace0\ub11b\uc774 \ud65c\uc131\ud654\ub41c\ub2e4. \ud65c\uc131\ud654\ub41c \uc544\uace0\ub11b\uc740 \uc790\uc2e0\uacfc \uc11c\uc5f4\uc774 \ub9de\ub294 \ud45c\uc801 \uc720\uc804\uc790(mRNA)\ub97c \ucc3e\uc544 \uc120\ud0dd\uc801\uc73c\ub85c \uc5b5\uc81c\ud55c\ub2e4. \ubc15\uc2a4 \uc548\uc758 \uadf8\ub9bc\uc740 \uc0e4\ud398\ub860\uc5d0 \uacb0\ud569\ud55c \uc5f4\ub9b0 \uc544\uace0\ub11b \uc0c1\ud0dc(\uc67c\ucabd)\uc640 miRNA \ud0d1\uc7ac \ud6c4 \ud615\uc131\ub418\ub294 \ud65c\uc131\ud654\ub41c \uc544\uace0\ub11b \uc0c1\ud0dc(\uc624\ub978\ucabd)\ub97c \ubcf4\uc5ec\uc900\ub2e4.<\/p>\n\n\n
\uc5f0\uad6c\uc9c4 \uc774\ub825\uc0ac\ud56d<\/td>\n<\/tr>\n<\/table>\n

<\uae40\ube5b\ub0b4\ub9ac IBS RNA \uc5f0\uad6c\ub2e8\uc7a5, \uacf5\ub3d9 \uad50\uc2e0\uc800\uc790><\/p>\n

1. \uc778\uc801\uc0ac\ud56d<\/p>\n

\u25cb \uc18c \uc18d : \uae30\ucd08\uacfc\ud559\uc5f0\uad6c\uc6d0(IBS) RNA \uc5f0\uad6c\ub2e8\uc7a5<\/p>\n

\u25cb \uc804 \ud654 : 02-880-9120<\/p>\n

\u25cb e-mail : narrykim@ibs.re.kr \/ narrykim@snu.ac.kr<\/p>\n

2. \ud559\ub825<\/p>\n

\u25cb 1988 \u2013 1992 : \uc11c\uc6b8\ub300\ud559\uad50 \ubbf8\uc0dd\ubb3c\ud559\uacfc \ud559\uc0ac<\/p>\n

\u25cb 1992 \u2013 1994 : \uc11c\uc6b8\ub300\ud559\uad50 \ubbf8\uc0dd\ubb3c\ud559\uacfc \uc11d\uc0ac<\/p>\n

\u25cb 1994 \u2013 1998 : Oxford University \uc0dd\ud654\ud559 \ubc15\uc0ac<\/p>\n

3. \uacbd\ub825\uc0ac\ud56d<\/p>\n

\u25cb 1999 \u2013 2001 : \u7f8e University of Pennsylvania \ubc15\uc0ac\ud6c4\uc5f0\uad6c\uc6d0<\/p>\n

\u25cb 2001 \u2013 2004 : \uc11c\uc6b8\ub300\ud559\uad50 \uc5f0\uad6c\uc870\uad50\uc218<\/p>\n

\u25cb 2004 \u2013 \ud604\uc7ac : \uc11c\uc6b8\ub300\ud559\uad50 \uc0dd\uba85\uacfc\ud559\ubd80 \uc870\uad50\uc218, \ubd80\uad50\uc218, \uad50\uc218<\/p>\n

\u25cb 2006 \u2013 2008 : \uad6d\uac00\uacfc\ud559\uae30\uc220\uc790\ubb38\ud68c\uc758 \uc704\uc6d0<\/p>\n

\u25cb 2010 \u2013 2012 : \uad50\uc721\uacfc\ud559\uae30\uc220\ubd80\u00b7\ud55c\uad6d\uc5f0\uad6c\uc7ac\ub2e8 \uc9c0\uc815 \uad6d\uac00\uacfc\ud559\uc790<\/p>\n

\u25cb 2010 \u2013 2016 : \uc11c\uc6b8\ub300\ud559\uad50 \uc911\uacac \uc11d\uc88c\uad50\uc218<\/p>\n

\u25cb 2010 \u2013 \ud604\uc7ac : Cell \ud3b8\uc9d1\uc704\uc6d0<\/p>\n

\u25cb 2011 \u2013 2012 : International RNA Society \ub514\ub809\ud130<\/p>\n

\u25cb 2012 \u2013 \ud604\uc7ac : IBS RNA \uc5f0\uad6c\ub2e8\uc7a5<\/p>\n

\u25cb 2013 \u2013 2014 : \uad6d\uac00\uacfc\ud559\uae30\uc220\uc790\ubb38\ud68c\uc758 \uc704\uc6d0<\/p>\n

\u25cb 2013 \u2013 \ud604\uc7ac : \uc720\ub7fd\ubd84\uc790\uc0dd\ubb3c\ud559\uae30\uad6c(EMBO) \uc678\uad6d\uc778 \ud68c\uc6d0<\/p>\n

\u25cb 2014 \u2013 \ud604\uc7ac : \ubbf8\uad6d \uad6d\ub9bd\uacfc\ud559\uc6d0(NAS) \uc678\uad6d\uc778 \ud68c\uc6d0<\/p>\n

\u25cb 2014 \u2013 \ud604\uc7ac : \ud55c\uad6d\uacfc\ud559\uae30\uc220\ud55c\ub9bc\uc6d0 \ud68c\uc6d0<\/p>\n

\u25cb 2015 \u2013 \ud604\uc7ac : Science \ud3b8\uc9d1\uc704\uc6d0<\/p>\n

\u25cb 2017 \u2013 \ud604\uc7ac : \uc11c\uc6b8\ub300\ud559\uad50 \uc11d\uc88c\uad50\uc218<\/p>\n

\u25cb 2021 \u2013 \ud604\uc7ac : \uc601\uad6d \uc655\ub9bd\ud559\ud68c(Royal Society) \uc678\uad6d\uc778 \ud68c\uc6d0<\/p>\n

4. \uc218\uc0c1\uc2e4\uc801<\/p>\n

\u25cb 2007 : \uacfc\ud559\uae30\uc220\uc815\ubcf4\ud1b5\uc2e0\ubd80 \uc80a\uc740\uacfc\ud559\uc790\uc0c1<\/p>\n

\u25cb 2007 : Thompson Scientific Citation Award<\/p>\n

\u25cb 2008 : \ub85c\ub808\uc54c-\uc720\ub124\uc2a4\ucf54 \uc5ec\uc131\uacfc\ud559\uc790\uc0c1<\/p>\n

\u25cb 2009 : \ud638\uc554\uc0c1 \uc758\ud559 \ubd80\ubb38<\/p>\n

\u25cb 2010 : \uc544\ubaa8\ub808\ud37c\uc2dc\ud53d \uc5ec\uc131\uacfc\ud559\uc790\uc0c1<\/p>\n

\u25cb 2013 : \uc5d0\uc4f0\uc624\uc77c \uc120\ub3c4\uacfc\ud559\uc790 \ud3a0\ub85c\uc2ed<\/p>\n

\u25cb 2013 : \ub300\ud55c\ubbfc\uad6d \ucd5c\uace0\uacfc\ud559\uae30\uc220\uc778\uc0c1<\/p>\n

\u25cb 2017 : Chen Award<\/p>\n

\u25cb 2019 : \uc544\uc0b0\uc758\ud559\uc0c1 \uae30\ucd08\uc758\ud559 \ubd80\ubb38<\/p>\n

\u25cb 2021 : \uc81c4\ud68c \ub77c\uc774\ub09850+\uc5b4\uc6cc\uc988 \ub300\uc0c1<\/p>\n

\u25cb 2024 : \uc81c3\ud68c \uc784\uc131\uae30\uc5f0\uad6c\uc790\uc0c1 \ub300\uc0c1<\/p>\n

\u25cb 2025 : \uc81c24\ud68c \ud55c\uad6d\ubd84\uc790\u00b7\uc138\ud3ec\uc0dd\ubb3c\ud559\ud68c \uc0dd\uba85\uacfc\ud559\uc0c1<\/p>\n

<\uc774\uc601\uc724 IBS RNA \uc5f0\uad6c\ub2e8 \uc5f0\uad6c\uc6d0, \uacf5\ub3d9 \uc81c1\uc800\uc790><\/p>\n

\u25cb \uc18c \uc18d : \uae30\ucd08\uacfc\ud559\uc5f0\uad6c\uc6d0(IBS) RNA \uc5f0\uad6c\ub2e8<\/p>\n

\u25cb \uc804 \ud654 : 02-880-6697<\/p>\n

\u25cb e-mail : leeyou20@snu.ac.kr<\/p>\n

\u25cb 2010 \u2013 2016 : University of Toronto, \ud559\uc0ac<\/p>\n

\u25cb 2017 \u2013 2023 : \uc11c\uc6b8\ub300\ud559\uad50, \ubc15\uc0ac<\/p>\n

\u25cb 2017 \u2013 2024 : IBS RNA \uc5f0\uad6c\ub2e8 \uc5f0\uad6c\uc6d0<\/p>\n

\u25cb 2024 \u2013 \ud604\uc7ac : \uc2a4\uc704\uc2a4 \uc5f0\ubc29 \uacf5\uacfc\ub300\ud559\uad50(ETH Z\u00fcrich) \ubc15\uc0ac\ud6c4\uc5f0\uad6c\uc6d0<\/p>\n

\u25cb 2024 : \uc81c14\ud68c \uc5d0\uc4f0\uc624\uc77c \uc6b0\uc218\ud559\uc704\ub17c\ubb38\uc0c1<\/p>\n

<\uc815\ubbfc\uc11d IBS RNA \uc5f0\uad6c\ub2e8 \uc5f0\uad6c\uc6d0, \uacf5\ub3d9 \uc81c1\uc800\uc790><\/p>\n

\u25cb e-mail : haengju@snu.ac.kr<\/p>\n

\u25cb 2017 \u2013 2019 : \uc11c\uc6b8\ub300\ud559\uad50 \ubc14\uc774\uc624\uc18c\uc7ac\uacf5\ud559\uc804\uacf5 (Pre-Pharmacy)<\/p>\n

\u25cb 2019 \u2013 2023 : \uc11c\uc6b8\ub300\ud559\uad50 \uc57d\ud559\uacfc (Pharm.D.)<\/p>\n

\u25cb 2023 \u2013 \ud604\uc7ac : \uc11c\uc6b8\ub300\ud559\uad50 \uc0dd\uba85\uacfc\ud559\ubd80 \uc11d\ubc15\uc0ac\ud1b5\ud569\uacfc\uc815 (\uc218\ub8cc)<\/p>\n

\u25cb 2023 – \ud604\uc7ac : IBS RNA \uc5f0\uad6c\ub2e8 \uc5f0\uad6c\uc6d0<\/p>\n

\u25cb 2018 : \uc1a1\uc6d0\uae40\uc601\ud658\uc7a5\ud559\uc7ac\ub2e8 \uc7a5\ud559\uc0dd \uc120\ubc1c<\/p>\n

\u25cb 2022 : \ubaa9\uc554\uacfc\ud559\uc7a5\ud559\uc7ac\ub2e8 \uc7a5\ud559\uc0dd \uc120\ubc1c<\/p>\n

\u25cb 2023 : \uc11c\uc6b8\ub300\ud559\uad50 \ucd1d\ub3d9\ucc3d\ud68c\uc7a5\uc0c1<\/p>\n

\u25cb 2024 : \ub300\ud559\uc6d0 \ub300\ud1b5\ub839\uacfc\ud559\uc7a5\ud559\uc0dd \uc120\ubc1c<\/p>\n

<\ub178\uc131\ud6c8 \uc11c\uc6b8\ub300\ud559\uad50 \uc0dd\uba85\uacfc\ud559\ubd80 \uad50\uc218, \uacf5\ub3d9 \uad50\uc2e0\uc800\uc790><\/p>\n

\u25cb \uc18c \uc18d : \uc11c\uc6b8\ub300\ud559\uad50 \uc0dd\uba85\uacfc\ud559\ubd80 \ubd80\uad50\uc218<\/p>\n

\uc138\ud3ec \ubc0f \uac70\ub300\ubd84\uc790 \uc774\ubbf8\uc9d5 \ud575\uc2ec\uc9c0\uc6d0\uc13c\ud130 \uc13c\ud130\uc7a5<\/p>\n

\u25cb \uc804 \ud654 : 02-880-2135<\/p>\n

\u25cb e-mail : shroh@snu.ac.kr<\/p>\n

\u25cb 1994 \u2013 2001 : \uacbd\ubd81\ub300\ud559\uad50 \ud559\uc0ac<\/p>\n

\u25cb 2001 \u2013 2003 : \uad11\uc8fc\uacfc\ud559\uae30\uc220\uc6d0 \uc11d\uc0ac<\/p>\n

\u25cb 2009 \u2013 2015 : Baylor College of Medicine (US) \ubc15\uc0ac<\/p>\n

\u25cb 2004 \u2013 2009 : LG \uc0dd\uba85\uacfc\ud559<\/p>\n

\u25cb 2015 \u2013 2017 : Baylor College of Medicine (US) \ubc15\uc0ac\ud6c4\uc5f0\uad6c\uc6d0<\/p>\n

\u25cb 2017 \u2013 2018 : Stanford University (US) \ubc15\uc0ac\ud6c4\uc5f0\uad6c\uc6d0<\/p>\n

\u25cb 2018 \u2013 2022 : \uc11c\uc6b8\ub300\ud559\uad50 \uc0dd\uba85\uacfc\ud559\ubd80 \uc870\uad50\uc218<\/p>\n

\u25cb 2020 \u2013 \ud604\uc7ac : \uad50\uc721\ubd80 \uc138\ud3ec \ubc0f \uac70\ub300\ubd84\uc790 \uc774\ubbf8\uc9d5 \ud575\uc2ec\uc9c0\uc6d0\uc13c\ud130 \uc13c\ud130\uc7a5<\/p>\n

\u25cb 2021 \u2013 \ud604\uc7ac : \uc5f0\uad6c\uc7ac\ub2e8 \ucc28\uc138\ub300 \ubc14\uc774\uc624\uc774\ubbf8\uc9d5 \uae30\uc220\uac1c\ubc1c \uc0ac\uc5c5\ub2e8 \ub2e8\uc7a5<\/p>\n

\u25cb 2022 \u2013 \ud604\uc7ac : \uc11c\uc6b8\ub300\ud559\uad50 \uc0dd\uba85\uacfc\ud559\ubd80 \ubd80\uad50\uc218<\/p>\n

\u25cb 2020 : \uc11c\uacbd\ubc30\uacfc\ud559\uc7ac\ub2e8, SUHF Fellow<\/p>\n

\u25cb 2023 : \uc11c\uc6b8\ub300\ud559\uad50 \uc790\uc5f0\uacfc\ud559\ub300\ud559 \uad50\uc721\uc0c1<\/p>\n

<\uc774\ud55c\uc194 \uace0\ub824\ub300\ud559\uad50 \uc0dd\uba85\uc815\ubcf4\uacf5\ud559\uacfc \uad50\uc218, \uacf5\ub3d9 \uc81c1\uc800\uc790><\/p>\n

\u25cb \uc18c \uc18d : \uace0\ub824\ub300\ud559\uad50 \uacfc\ud559\uae30\uc220\ub300\ud559 \uc0dd\uba85\uc815\ubcf4\uacf5\ud559\uacfc \uc870\uad50\uc218<\/p>\n

\u25cb \uc804 \ud654 : 044-860-1416<\/p>\n

\u25cb e-mail : leehansol@korea.ac.kr<\/p>\n

\u25cb 2007 \u2013 2012 KAIST \uc0dd\uba85\uacfc\ud559\uacfc \ud559\uc0ac<\/p>\n

\u25cb 2012 \u2013 2018 KAIST \uc0dd\uba85\uacfc\ud559\uacfc \ubc15\uc0ac (\uc11d\ubc15\ud1b5\ud569\uacfc\uc815)<\/p>\n

\u25cb 2018 \u2013 2020 : KAIST \uc790\uc5f0\uacfc\ud559\uc5f0\uad6c\uc18c \uc5f0\uc218\uc5f0\uad6c\uc6d0<\/p>\n

\u25cb 2021 \u2013 2023 : \uc11c\uc6b8\ub300\ud559\uad50 \uc720\uc804\uacf5\ud559\uc5f0\uad6c\uc18c \uc5f0\uc218\uc5f0\uad6c\uc6d0<\/p>\n

\u25cb 2023 \u2013 2024 : \uc11c\uc6b8\ub300\ud559\uad50 \uc0dd\uba85\uacfc\ud559\ubd80 BK\uc5f0\uc218\uc5f0\uad6c\uc6d0<\/p>\n

\u25cb 2024 \u2013 2025 : \uc11c\uc6b8\ub300\ud559\uad50 \uc0dd\uba85\uacfc\ud559\ubd80 BK\uc5f0\uad6c\uc870\uad50\uc218<\/p>\n

\u25cb 2025 \u2013 \ud604\uc7ac : \uace0\ub824\ub300\ud559\uad50 \uc0dd\uba85\uc815\ubcf4\uacf5\ud559\uacfc \uc870\uad50\uc218<\/p>\n<\/div>\n<\/div>\n

\n
\n

\ud0dc\uadf8<\/strong><\/p>\n

#\uc544\uace0\ub11b<\/a> #\ub2e8\ubc31\uc9c8<\/a> #RNA \uce58\ub8cc\uc81c<\/a> #\uc720\uc804\uc790 \uc870\uc808<\/a> #\uc0e4\ud398\ub860<\/a> #miRNA<\/a> #\ubcf5\ud569\uccb4<\/a> #\uad6c\uc870 \ubd84\uc11d<\/a> #\uce58\ub8cc\uc81c \uc124\uacc4<\/a> #\ub300\uc0ac\uc9c8\ud658<\/a><\/p>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

– IBS\uff65\uc11c\uc6b8\ub300, \ubca0\uc77c\uc5d0 \uc2f8\uc600\ub358 \uc720\uc804\uc790 \uc870\uc808 \ub2e8\ubc31\uc9c8 \ud65c\uc131\ud654 \uc6d0\ub9ac \uc138\uacc4 \ucd5c\ucd08 \uaddc\uba85 – RNA \uce58\ub8cc\uc81c \uc124\uacc4\uc758 \uc2dc\ud589\ucc29\uc624\ub97c \uc904\uc77c \uc0c8\ub85c\uc6b4 \ubc29\ud5a5 \uc81c\uc2dc, \uad6d\uc81c\ud559\uc220\uc9c0 Nature\u8a8c \uac8c\uc7ac \ub300\uc0ac\uc9c8\ud658, \uc54c\uce20\ud558\uc774\uba38 \ub4f1 \ud2b9\uc815 \uc720\uc804\uc790\uac00 \uacfc\ub3c4\ud558\uac8c \ubc1c\ud604\ub418\uc5b4 \uc0dd\uae30\ub294 \ub09c\uce58\uc131 \uc9c8\ud658\uc758 RNA \uce58\ub8cc\uc81c\ub97c \ubd80\uc791\uc6a9 \uc5c6\uc774 \ubcf4\ub2e4 \uc815\uad50\ud558\uac8c \uc124\uacc4\ud560 \uc218 \uc788\ub294 \uae38\uc774 \uc5f4\ub9b4 \uc804\ub9dd\uc774\ub2e4. \uacfc\ud559\uae30\uc220\uc815\ubcf4\ud1b5\uc2e0\ubd80(\ubd80\ucd1d\ub9ac \uacb8 \uacfc\ud559\uae30\uc220\uc815\ubcf4\ud1b5\uc2e0\ubd80 \uc7a5\uad00 \ubc30\uacbd\ud6c8, \uc774\ud558 \u2018\uacfc\uae30\uc815\ud1b5\ubd80\u2019)\ub294 \uae30\ucd08\uacfc\ud559\uc5f0\uad6c\uc6d0(\uc6d0\uc7a5 \uc7a5\uc11d\ubcf5, […]<\/p>\n","protected":false},"author":19,"featured_media":974,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[3622,3619,3624,3618,3626,3623,3621,3617,3620,3625],"class_list":["post-975","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2","tag-mirna","tag-rna-","tag-3624","tag-3618","tag-3626","tag-3623","tag-3621","tag-3617","tag-3620","tag-3625"],"yoast_head":"\n\uc6b0\ub9ac \ubab8\uc758 \uc720\uc804\uc790 \uc0ac\ub0e5\uafbc \u2018\uc544\uace0\ub11b\u2019 \ub2e8\ubc31\uc9c8 \ud615\uc131 \uacfc\uc815 \uaddc\uba85 - 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